Meglitinides belong to a class of oral medications used in managing Type 2 diabetes, which includes Repaglinide and Nateglinide. 

Drug Family and Names: 

• Repaglinide: A rapid-acting meglitinide. 
• Nateglinide: Another meglitinide used in diabetes management. 

Mechanism of Action: 

Meglitinides work by stimulating the pancreas to release insulin, promoting a rapid increase in insulin production, particularly after meals, aiding in lowering blood sugar levels. 

Indications: 

Repaglinide and Nateglinide are prescribed: 

• To lower elevated blood sugar levels primarily after meals in individuals with Type 2 diabetes. 
• Often used when dietary modifications or other oral medications are not sufficient for blood sugar control. 

Side Effects: 

Common side effects of Meglitinides include: 

• Hypoglycemia (low blood sugar) 
• Weight gain 
• Gastrointestinal discomfort (nausea, diarrhea) 

Dosage: 

Dosage typically involves taking medication before each meal to match the mealtime insulin needs. Dosage and frequency are individualized based on meal patterns and blood sugar levels. 

Route of Administration: 

Meglitinides, such as Repaglinide and Nateglinide, are administered orally in the form of tablets, usually taken before meals. 

Precautions and Considerations: 

• Meglitinides should be taken with meals to avoid hypoglycemia. 
• Close monitoring of blood sugar levels is crucial, especially during dose adjustments or changes in meal patterns. 
• Use with caution in individuals with impaired liver function. 

Meglitinides, including Repaglinide and Nateglinide, offer rapid-acting insulin stimulation to manage post-meal blood sugar spikes in Type 2 diabetes. However, the risk of hypoglycemia necessitates close monitoring and adherence to prescribed dosages.