Meglitinides belong to a class of oral medications used in managing Type 2 diabetes, which includes Repaglinide and Nateglinide.
Drug Family and Names:
- Repaglinide: A rapid-acting meglitinide.
- Nateglinide: Another meglitinide used in diabetes management.
Mechanism of Action:
Meglitinides work by stimulating the pancreas to release insulin, promoting a rapid increase in insulin production, particularly after meals, aiding in lowering blood sugar levels.
Indications:
Repaglinide and Nateglinide are prescribed:
- To lower elevated blood sugar levels primarily after meals in individuals with Type 2 diabetes.
- Often used when dietary modifications or other oral medications are not sufficient for blood sugar control.
Side Effects:
Common side effects of Meglitinides include:
- Hypoglycemia (low blood sugar)
- Weight gain
- Gastrointestinal discomfort (nausea, diarrhea)
Dosage:
Dosage typically involves taking medication before each meal to match the mealtime insulin needs. Dosage and frequency are individualized based on meal patterns and blood sugar levels.
Route of Administration:
Meglitinides, such as Repaglinide and Nateglinide, are administered orally in the form of tablets, usually taken before meals.
Precautions and Considerations:
- Meglitinides should be taken with meals to avoid hypoglycemia.
- Close monitoring of blood sugar levels is crucial, especially during dose adjustments or changes in meal patterns.
- Use with caution in individuals with impaired liver function.
Meglitinides, including Repaglinide and Nateglinide, offer rapid-acting insulin stimulation to manage post-meal blood sugar spikes in Type 2 diabetes. However, the risk of hypoglycemia necessitates close monitoring and adherence to prescribed dosages.